In the case of defects in key DNA repair molecules such as bloom syndrome protein (BLM), Werner syndrome protein (WRN), ATM, and lamin A/C (LMNA) can lead to long-term chronic inflammation that disrupts the balance of the oxidation/reduction system and causes continuous accumulation of gene mutations, ultimately resulting in serious disorders such as cancer and senescence [137–141]. The gene discussed is WRN; the disease is cancer.