In a study on leukemia, Valleron et al. [88] found that SNORD114-1 [14q(II-1)] positively regulates the phosphorylation of Rb at the Ser780 site, thereby controlling the distribution of G1/S phase through the Rb/p16 pathway and impacting the proliferation and differentiation of leukemia cells. The gene discussed is RB1; the disease is leukemia.