Therefore, [99mTc]Tc-PSMA SPECT/CT may have broader clinical applicability than [68Ga]Ga-PSMA PET/CT, which may provide uro-oncologists and nuclear medicine physicians with more options in the diagnosis of prostate cancer, especially when [68Ga]Ga-PSMA PET/CT is not yet widely available. The gene discussed is FOLH1; the disease is Familial prostate cancer.