Although some brain tumors (such as dysembryoplastic neuroepithelial tumor (DNET) and diffuse midline glioma [15–17]) also present the T2-FLAIR mismatch sign, this sign highly specific for astrocytoma, IDH-mutant among patients with lower grade glioma [8, 11]. Here, IDH1 is linked to dysembryoplastic neuroepithelial tumor.