In particular to the MENA region, the IL-28B rs12979860 SNP was found to predict the consequence of HCV genotype 3a infection in the Iranian population, along with the IL-28B rs8099917 and IL-28B rs8103142 SNPs among HCV GT4-infected Egyptians [26, 35, 45]. A Tunisian study further confirmed the significance of IL-28B rs12979860 variation in predicting treatment response and toxicity [46].The same association results were reported among Caucasians, African Americans, and Hispanics [41, 43, 44]. This evidence concerns the gene IFNL3 and infection.