Furthermore, we observe that samples from DLBCL patients with low GNAS expression (“GNAS low”) display a high level of baseline TE expression and a pro-IFN state, and share common disrupted biological activities in histone modification, mRNA processing, and transcriptional regulation with GNAS KO DLBCL cells, suggesting a potential viral mimicry-primed condition in GNAS low DLBCL for enhanced response to HDAC3 inhibition. The gene discussed is HDAC3; the disease is diffuse large B-cell lymphoma.