Intriguingly, the GNAS low-associated downregulated terms identified from the two independent clinical DLBCL cohorts were also detected in the cultured GNAS KO human DLBCL cells (both sgGNAS2 and sgGNAS3; Supplementary Fig. 9; see Supplementary Data 5 for the full results of GSEA analysis), indicating common cell-intrinsic effects of GNAS deficiency on DLBCL biology. The gene discussed is GNAS; the disease is diffuse large B-cell lymphoma.