Together with our results showing upregulated dsRNA formation and TE expression, our functional evaluation based on TBK1, IRF3, and JAK1 provides direct evidence for the causal link between GNAS KO-induced sensitization and viral mimicry induction regardless of the upstream inputs, addressing a general knowledge gap between isoform-selective HDAC inhibition (e.g., HDAC3 inhibition) and viral mimicry in cancer. Here, HDAC3 is linked to cancer.