GNAS and neoplasm: While these results provide an interesting perspective on the potential immune responses associated with GNAS KO and HDAC3 inhibition, further studies are needed to confirm the effects of cytokines and explore the role of tumor neoantigens and upregulation of MHC complexes in enhancing T cell-induced cytotoxicity as well as the effects of immunotherapy such as checkpoint inhibitors and CAR-T cell therapy.