GNAS and diffuse large B-cell lymphoma: Importantly, together with validation using an additional independent cohort of 481 DLBCL transcriptome samples as well as analysis of our cell-line data, we identified three common biological themes—histone modification, mRNA processing, and transcriptional regulation—that were disrupted in both GNAS low DLBCL patients and GNAS KO DLBCL cells.