More specifically, DNA methyltransferase inhibitors (DNMTis) such as 5-azacytidine (AZA) and 5-Aza-2′-deoxycytidine (5-AZA-CdR) are shown to derepress transcription of repetitive TE sequences, particularly retrotransposons such as endogenous retroviruses from the long-terminal repeat (LTR) family, leading to the formation of dsRNAs and induction of robust cell-intrinsic anti-tumor IFN responses [31, 32]. The gene discussed is IFNA1; the disease is neoplasm.