Histone deacetylase 3 (HDAC3) is recruited by the transcription repressor BCL6 to form a deacetylation complex with SMRT and NCoR to counteract the activity of CREBBP for gene enhancer regulation, which maintains the unopposed deacetylation state in CREBBP-mutant lymphoma [5, 6, 10]. Here, CREBBP is linked to lymphoma.