OS did not significantly differ by tumor differentiation or Ki-67 index, although the median OS was notably higher for G3 neuroendocrine tumors (NETs) versus NECs (23.3 vs. 13.9 months, HR: 1.37; 95% CI: 0.5–3.5), and for Ki-67 ≤ 55 versus >55% (17.6 vs. 11.7 months, HR: 0.97; 95% CI: 0.4–2.4) (Supplementary Fig. 1). The gene discussed is MKI67; the disease is neuroendocrine neoplasm.