KMT2D and head and neck squamous cell carcinoma: Interestingly, inconsistent with previous studies showing that H3K4me1 peaks usually occupy enhancer regions, our ChIP-seq data showed that KMT2D regulated the FA gene expressions by modulating H3K4me1, H3K27ac, and H3K4me3 levels at the promoters near TSS in HNSCC cells under glycolytic suppression, revealing another regulatory mechanism by which KMT2D controls gene expression.