AP1 is a heterodimer, composed of c-Fos and c-Jun subunits.32 It had been previously reported that hepatic AP1 activity was increased in diabetic mice, and lentiviral-mediated knockdown of hepatic AP1 alleviated insulin resistance and fatty liver.33,34 Then, whether RIMKLA repressed FASn and CD36 expression via the inhibition of AP1 was determined. This evidence concerns the gene FASN and Insulin resistance.