Disulfidiptosis, characterized by an overabundance of cysteine and atypical disulfide bonds within cytoskeletal proteins resulting from increased SLC7A11 expression in low-glucose conditions, has the potential to serve as a significant biomarker for immune infiltration, drug response, and prognosis in HCC [100, 101]. The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.