PMEL and infection: Repetitive antigen stimulation is recognized to drive CD8+ T cells towards senescence, while progressively reducing the pool of stem-like T cells.29 We found that enforced expression of Lmo4 reduced the percentage of CD62L−KLRG1+ terminal effectors whereas it doubled the frequencies of stem-like CD62L+KLRG1− T cells 30 days after secondary infection with gp100-Adv (Fig. 2f–h).