Interestingly, many of the upregulated genes in this network, including JUNB, JUN, FOS, FOSB, and ZFP36, were recently found to be enriched in a subset of highly functional T cells isolated from human head and neck squamous cell carcinoma,47 underscoring its potential relevant role in enhancing the antitumor effectiveness of LMO4-overexpressing T cells. Here, FOS is linked to head and neck squamous cell carcinoma.