Through in vivo experiments, we discovered that silencing S100A10 inhibited the growth and migration of tumors in NOD-SCID mice and restored the functionality of CD8+ T cells within the tumor tissues, indicating effective suppression of CD8+ T cell exhaustion in tumor tissues by S100A10 silencing, thereby inhibiting immune escape of HCC cells. The gene discussed is CD8A; the disease is hepatocellular carcinoma.