IFNG and colitis: Correspondingly, the EGCG-mediated alterations in GPR43-related signaling components, including decreased nuclear expressions of p-p50 and p-p65, as well as decreased cytoplasmic expressions of IL-12 and IFN-γ levels in the colon, were restored to levels similar to the DSS group upon GLPG intervention in colitis mice (Fig. 4G and H).