Correspondingly, the EGCG-mediated alterations in GPR43-related signaling components, including decreased nuclear expressions of p-p50 and p-p65, as well as decreased cytoplasmic expressions of IL-12 and IFN-γ levels in the colon, were restored to levels similar to the DSS group upon GLPG intervention in colitis mice (Fig. 4G and H). This evidence concerns the gene NFKB1 and colitis.