Eight of nine specimens withATXN1 mutations were associated with advanced-stage disease,suggesting involvement in epithelial-mesenchymal transition and cancer metastasis (Campbell et al., 2021).CDC42EP1, a member of the Rho GTPase family, represents a novelplayer in cancer development, particularly in OTSCC (Campbell et al., 2021). The gene discussed is CDC42EP1; the disease is cancer.