Inscrutinizing 227 specimens from eight diverse sources, including 107 early-onset cases,their analysis identified seven putative driver genes for OTSCC, unveiling two hithertounreported genes-ATXN1 and CDC42EP1. Impressively,82.8% of specimens exhibited missense or truncating mutations in at least one of theseseven genes, with TP53 emerging as the most frequently mutated (63.0%).Another study from MD Anderson (Cancer Discovery Project), shows TP53as the most mutated gene in OSCC patients (Figure3A), being R175H and R110L the most recurrent mutations (Figure 3B). Here, CDC42EP1 is linked to cancer.