CDKN2A and head and neck squamous cell carcinoma: CDKN2A, universally inactivated in non-HPV-related HNSCC, displayedvariable mutation rates in our study, akin to earlier reports in oral cavity cancer(Lawrence et al., 2015).NOTCH1, a participant in the squamous differentiation Notch pathwayacting as a tumor suppressor in oral cavity carcinogenesis (Pickering et al., 2013), exhibited similar mutation rates in oralcavity SCC (Pickering et al.,2013) and in the OTSCC cohort (Campbell etal., 2021), though disruptions in the Notch pathway were absent (Pickering et al., 2013).