To summarize, PTBP3‐mediated exon skipping of IL‐18 dramatically changes its function in gallbladder cancer; while cIL‐18 inhibits tumor growth, ΔIL‐18 down‐regulates FBXO38 transcription levels in CD8+T cells to reduce PD‐1 ubiquitin‐mediated degradation, thereby promoting gallbladder cancer immune escape. Here, FBXO38 is linked to gallbladder cancer.