IL‐18 is a myeloid leukocyte inflammatory mediator whose primary function is to induce IFNγ secretion by T cells and NK cells.[33] In a mouse model, IL‐18 expression enhanced T cell proliferation, cytotoxicity, and persistence, thereby inhibiting tumor progression.[34] In vitro experiments showed that r IL‐18 did not have an obvious effect on the proliferative capacity of gallbladder tumor cells (Figure S4A, Supporting Information). This evidence concerns the gene IFNG and gallbladder neoplasm.