The tumor isoform encoded an IL‐15 protein with a 21‐amino‐acid signal peptide (SP), which was shorter than the classic IL‐15 SP (48 amino acids).[51, 52] Only 48SP‐IL‐15 enhanced protective responses against pathogens, whereas 21SP‐IL‐15 appeared to be immunosuppressive.[53] Thus, combined with sequencing data and clinical sample validation, we can speculate that alterations in splicing during gallbladder cancer progression may favor the production of ΔIL‐18, the isoform involved in immune escape. This evidence concerns the gene IL15 and gallbladder cancer.