That said, our E-value of 3.59 indicates that, in addition to the measured covariates that were included, an unmeasured covariate (like obesity) would need to be associated with both GLP-1-RA use and all-cause mortality by a risk ratio of 3.59 to nullify our findings. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.