MINDY Lysine 48 Deubiquitinase 2 (MINDY2) interacts with and deubiquitinates ACTN4, stabilizes ACTN4, and activates the PI3K/AKT/mTOR signaling pathway to promote pancreatic cancer proliferation and metastasis [20]. The gene discussed is MTOR; the disease is familial pancreatic carcinoma.