Most importantly, the high abundance of ROCK1, ROCK2, MYLK, and CALM2 in patients with early-onset POAG suggests that these proteins are actively involved in the disease mechanism, particularly through their role in myosin light chain phosphorylation and subsequent cellular contractions that elevate IOP and may be a key contributor to the occurrence of early-onset POAG. The gene discussed is CALM2; the disease is open-angle glaucoma.