In this study, we analyzed the expression and subcellular localization of a number of NE proteins previously implicated in prostate cancer development, namely lamin A/C and lamin B1, and the inner nuclear membrane proteins emerin and β-dystroglycan (β-DG), using a cellular system consisting of the prostate epithelial cell line RWPE-1, and four prostate cancer cell lines with different metastatic potential WPE1-NA22, WPE1-NB14, WPE1-NB26 and DU145 [24]. This evidence concerns the gene EMD and Familial prostate cancer.