Obesity-related metabolic disorders often involve changes in other insulin-sensitive tissues like the liver and skeletal muscle, leading to conditions such as glucose intolerance.33,34 In this study, we observed that the injection of siAK029592 in BAT exerted a significant effect in counteracting CL316,243-induced alterations in whole-body glucose homeostasis. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.