For instance, microcephaly has been associated with mutations in RAB3GAP/RAB18 [111, 112], ARFGEF2 [113], ARF1 [114, 115], kinesin KIF2A [2], or dynein heavy chain [116], all affecting both membrane trafficking [117] and neuronal morphogenesis. Here, ARFGEF2 is linked to microcephaly.