Microcephaly, epilepsy, and diabetes syndrome-1 (MEDS1, OMIM #614231) is an autosomal recessive neurodevelopmental disorder characterized by microcephaly, simplified gyral pattern, severe epilepsy, and early-onset infantile diabetes mellitus caused by mutations in the IER3IP1 gene [4]. The gene discussed is IER3IP1; the disease is epilepsy.