In our study, we found that DR15 was significantly associated with interstitial lung disease in patients with Sjögren's syndrome; however, DR15 was not found to be associated with anti‐CCP antibody or anti‐Ro antibody, and anti‐CCP antibody and anti‐Ro antibody were not found to be associated with interstitial lung disease. Here, CALR is linked to interstitial lung disease.