Interestingly, oral ulcer was negatively associated with the presence of anti‐Ro antibodies (OR = 0.437, 95% CI 0.268–0.713, corrected p = 0.0043) and anti‐ENA antibodies (OR = 0.330, 95% CI 0.178–0.613, corrected p = 0.0032); in addition, there was a trend towards negative association with C4 hypocomplementemia (OR = 0.258, 95% CI 0.078–0.849, corrected p = 0.068). This evidence concerns the gene CALR and Oral ulcer.