In contrast to previous reports [27], Lkb1 haploinsufficiency promoted melanoma development via the activation of either one BrafCA/+ allele (18.1%) or both BrafCA/CA alleles (31.2%), albeit at late time points, as previously reported (mean onset times of 399 ± 38.9 and 285 ± 45 days, respectively). The gene discussed is STK11; the disease is melanoma.