UV‐independent myxoid‐like melanomas were absent in either BrafCA/+; Lkb1−/− or BrafCA/CA; Lkb1−/− and UV‐independent melanomas with neural differentiation were mainly present in mice harboring the activation of two alleles of Braf (BrafCA/CA) and the deletion of either one or both alleles of Lkb1 (Lkb1+/−; Lkb1−/−) (Fig. 4B). This evidence concerns the gene BRAF and melanoma.