These results show that the inclusion of D1MT to the cART regime in M. tuberculosis/SIV coinfection significantly increases the antigen-specific T cell response specific to proinflammatory Th1 and Th17 immunity, without increasing lung pathology (Figure 4); burdens of either M. tuberculosis (Figure 3) or SIV (Figure 5); or clinical markers of disease such as serum CRP or A/G ratio and 18-FDG incorporation in lung lesions (Figure 1). This evidence concerns the gene CRP and coinfection.