Notably, disturbances in the function of CD4+ Tregs have been observed in PwMS, with several studies reporting a significant decrease in suppressive ability.182,183 Additionally, CD8+ Treg function is deficient during acute exacerbation of MS.16,184 Thus, increasing Tregs in PwMS or improving Treg functionality remains an enticing potential therapeutic. This evidence concerns the gene CD8A and myeloid sarcoma.