GLI3 and Pallister-Hall syndrome: Finally, it is noteworthy that the GLI3 variants within regulatory islands under putative positive selection have ClinVar-associated phenotypes (Landrum et al., 2018), with the minor (ancestral) allele linked to Greig cephalopolysyndactyly syndrome (OMIM: 175700) and Pallister Hall syndrome (OMIM: 146510), which affect brain size and craniofacial traits among other clinical features.