On the other hand, LCAT has long been recognised as a key regulator of high-density lipoprotein metabolism; however, the role of this enzyme in human atherogenesis and ASCVD has remained controversial.13 Earlier studies reported increases14,15 and decreases3,5 in plasma LCAT activity and concentrations in patients with ASCVD. The gene discussed is LCAT; the disease is atherosclerosis.