HPN-AS1 and cancer: GABPA has been found to be crucial in suppressing tumors in various types of cancers.21,22 For instance, GABPA inhibits papillary thyroid carcinoma metastasis by enhancing DICER1 expression.23 GABPA suppresses HCC migration by positively modulating E-cadherin expression.22 Using sequence blast, we identified a potential GABPA-binding site in the HPN-AS1 promoter.