Hepatocellular carcinoma is a common primary hepatoma and ranks third among the cancer-associated causes of mortality.15 Long non-coding RNAs have a substantial impact on the advancement of HCC.7,16,17 According to the report, HCC showed a strong correlation with tumor mutation burden and immune infiltration, which was attributed to HPN-AS1.18 Prostate cancer diagnosis is possible using HPN-AS1 as well.19 Nevertheless, the precise molecular mechanisms through which HPN-AS1 governs cancer-related biological processes, particularly HCC, remain largely undisclosed. This evidence concerns the gene HPN and neoplasm.