Psoriasis, an immune-mediated inflammatory disorder of the skin, is characterized by the activation of IL-23–driven IL-17–producing T (T17) cells and other IL-23 receptor–positive IL-17–producing cell responses (Elloso et al, 2012; Hawkes et al, 2018; Kim et al, 2022; Lowes et al, 2008; Teng et al, 2015). The gene discussed is IL23R; the disease is psoriasis.