cGAS-STING KO by small interfering RNA resulted in a cisplatin-induced decrease in the phosphorylation of the downstream target proteins TBK1 and P65 in HK-2 cells, which ameliorated renal tubular inflammation and the extent of neutrophil infiltration in the tubular interstitium in mice with AKI (6). This evidence concerns the gene STING1 and acute kidney injury.