STAT1 and hereditary disease: To identify the genetic cause of this familial disorder, we used the Illumina’s TruSightTM One Panel to sequence DNA that was extracted from the older boy’s peripheral blood cells and focused our screening efforts on the three most likely responsible genes, namely, STAT1, IL17RA, and AIRE. This approach uncovered a hitherto undescribed heterozygous STAT1 missense variant c.1013G>T (p.Gly338Val) that affects the DNA-binding domain (Figure 2) (19).