INS and type 2 diabetes mellitus: miR-375 has previously been associated with beta cell loss in clinical islet transplantation and in streptozotocin-induced and NOD mouse models for diabetes (41, 42), while miR-483-5p originates from the INS-IGF2 locus on human chromosome 11 and has been shown to be upregulated in high glucose and associated with type 2 diabetes (43).