In murine models of syngeneic B16-F10 melanoma and CT-26 colon cancer, SAR444245 showed enhanced drug accumulation in tumor tissues, induced Ki67 expression in and expansion of tumor-infiltrating CD8+ T and NK cells, increased intra-tumoral T cell repertoire diversity and led to a dose-dependent reduction of tumor growth. The gene discussed is MKI67; the disease is neoplasm.