CXCR4 and neoplasm: Studies in solid tumors, as such the depletion of the transcription factor forkhead box P3 in mammary epithelial cells (62), the overexpression of transcription factor 12 in hepatocellular carcinoma (63), and the acetylation of transcription factor Krüppel-like factor 5 in prostate cancer (64) have been performed to evaluate the effects of CXCR4 modulation on tumor growth.