Lastly, CXCR2 expression by DCs induces their migration into the tumor through the CXCL8-CXCR2 axis (31, 32), since CXCL8, a CXCR2 ligand, is expressed by endothelial cells, tumor-associated macrophages (TAMs), and cancer cells. The gene discussed is CXCR2; the disease is neoplasm.