When secreted by intratumoral NK cells, XCL1, XCL2, and CCL5 serve as chemoattractants for type 1 conventional DCs (cDC1s), augmenting the recruitment of cDC1s into the TME where these powerful antigen-presenting cells can activate the cytotoxic CD8+ T lymphocytes (CTLs) for tumor attack (19, 20). Here, CD8A is linked to neoplasm.