In another study, a hydrogel nanoparticle complex, LPR@CHG, containing lipid-immune regulatory factor 5 mRNA/CCL5 siRNA (LPR) nanoparticle complexes coated with chitosan/HTCC/glycerophosphate was designed as a potential pancreatic cancer treatment (141). This evidence concerns the gene CCL5 and familial pancreatic carcinoma.