Given her high-risk profile (previous hydrops fetalis, hypothyroidism and high levels of anti-SSA/Ro antibodies), it was decided to initiate dexamethasone 8 mg/day (together with calcium and vitamin D3 supplementation) and intravenous immunoglobulin (IVIG) at a dose of 1 g/Kg (4). This evidence concerns the gene TRIM21 and hypothyroidism.