FOXO1 and Sepsis: In clinical studies and in in vivo models of sepsis, we have shown that elevation in circulating levels of HS precedes elevation in Angpt-2 levels; moreover, we observed that removal of HS from the eGC of HLMVEC promoted the upregulation in FoxO1 signaling to promote Angpt-2 upregulation (Richter et al., 2022a).