We have previously observed that plasma levels of HS rise in children with sepsis and in preclinical models of sepsis and that HS shedding from the eGC promotes aberrant EC signaling, evidenced by upregulation of the EC-derived cytokine angiopoietin-2 (Angpt-2) (Richter et al., 2022a). Here, ANGPT2 is linked to Sepsis.