LDLR and familial hyperaldosteronism: The p.E277K variant was initially discovered in a Swedish family in 1995 by (Ulf Ekström et al., 1995) and was predicted to cause FH until (Pereira et al., 1995) identified it in a small Cuban family and sequenced the entire LDLR coding region, showing that this variant co-segregated within the family and affected three members with FH while two remained unaffected.