Interestingly, in another study, both p.D178N and p.C243Y were previously identified along with p.C167L in both alleles of the LDLR gene in a 13-year-old Pakistani male with HoFH who exhibited severe phenotypic characteristics of FH and was being treated with (40 mg Atorvastatin and 10 mg Ezetimibe) (Marusic et al., 2020). Here, LDLR is linked to familial hyperaldosteronism.