The aberrant accumulation and distribution of Aβ, tau, alpha synuclein (α-syn), and TarDNA binding protein 43 (TDP-43) are common pathological features of neurodegenerative diseases, and this aberrant protein aggregation is exacerbated by sleep abnormalities (Owen and Veasey, 2020). Here, TARDBP is linked to neurodegenerative disease.