Bahader et al. (Bahader et al., 2023) found that when CI, a small molecule inhibitor of cofilin, acts on human neuroblastoma (SH-SY5Y) and microglia (HMC3), the expression of cofilin is significantly decreased, and the release of pro-inflammatory mediators is reduced, preventing the accumulation of ROS induced by H2O2 and neuronal cytotoxicity. The gene discussed is CFL1; the disease is neuroblastoma.