The Ras-related C3 botulinum toxin substrate 1 (Rac1)-WASP-family verprolin-homologous protein-2 (WAVE2)-actin-related protein 2/3 (Arp2/3) signaling pathway increases radiation resistance in U251 human glioma cells through CFL1 (Zhou et al., 2016). The gene discussed is RAC1; the disease is central nervous system cancer.