PSEN1 and Cognitive impairment: As an inhibitor of tyrosine protein kinase, it can improve cognitive impairment by reducing hyperphosphorylation of Tau (Petry et al., 2021), inhibiting neuronal death (Li et al., 2021), and decreasing inflammatory responses and oxidative stress (Shi B et al., 2023), etc. The Isoflavonoid biosynthesis pathway in which genistein participated played a potential biological role in preventing and slowing down cognitive dysfunction of APP/PS1 mice.