The pioneer TF FOXA1 and GATA2 have been previously linked to the regulation of ABCC4 expression in prostate cancer (Wu et al., 2014), where MRP4 has been validated as a clinically relevant prognostic marker associated with metastasis (Ho et al., 2008; Montani et al., 2013). Here, FOXA1 is linked to Familial prostate cancer.