Moreover, in both MRP4- and MRP4+ cell culture settings, we detected key signatures related to PDAC pathogenesis, specifically involving the KRAS and p53 pathways, as well as the inflammatory response, that play crucial roles in pancreatic tumor development and progression (Hausmann et al., 2014; Zhao et al., 2022). The gene discussed is ABCC4; the disease is pancreatic neoplasm.