Ma et al. found that the activation of silent information regulator 1 (SIRT1) by resveratrol alleviated myocardial damages in DCM through PGC-1α, NRF1, NRF2, ERR-α, and mitochondrial transcription factor A (TFAM)-mediated mitochondrial regulation (Ma et al., 2017). Here, TFAM is linked to familial dilated cardiomyopathy.