In particular, liver function enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), have been explored for their association with AD, cognitive function, and Aβ accumulation (Kellett et al., 2011; Nho et al., 2019; Lu et al., 2021; Ferri et al., 2022; Han et al., 2022; Li et al., 2022). The gene discussed is GPT; the disease is Alzheimer disease.