In the HUMC cohort, across all participants including those with SCD, MCI, and AD, low ALT levels were significantly associated with faster longitudinal decline in memory function (β [SE] = 0.035 [0.012], p = 0.029) in the APOE ε4 carrier group after adjustment for multiple comparisons (Table 8). This evidence concerns the gene APOE and Schnyder corneal dystrophy.