APOE and Alzheimer disease: As elucidated by D’Alonzo et al., the impact of the APOE ε4 allele on liver function involves impaired catabolism of lipoproteins, thereby increasing exposure to circulating lipoprotein-Aβ, which may lead to the Aβ aggregation in the brain and enhanced AD risk (D’Alonzo et al., 2023).