The incretin effect was estimated to account for approximately 50% - 70% of the postprandial insulin responses in healthy individuals and may be substantially reduced to 20% – 30% in individuals with type 2 diabetes mellitus (T2DM) (6, 7), a complex disorder arising from inadequate compensation of insulin secretion by pancreas to counter peripheral insulin resistance. This evidence concerns the gene INS and type 2 diabetes mellitus.