Platelets, being an important contributor of transforming growth factor-beta (TGF-β), initiate the activation of TGF-β/Smad and NF-κB signaling pathways in tumor cells resulting in their transition to a motile, invasive mesenchymal-like phenotype, a process called endothelial-mesenchymal transition or EMT. Here, TGFB1 is linked to neoplasm.