Importantly, α-granules serve as a primary reservoir for angiogenic factors such as VEGF, platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and basic fibroblast growth factor (bFGF) [47,48] through which, platelets stimulate angiogenesis in the tumor microenvironment (TME). The gene discussed is VEGFA; the disease is neoplasm.