Pulling in the opposite direction, and when stimulated by thromboxane A2, α-granules can downregulate angiogenesis within the tumor microenvironment (TME) by releasing a repertoire of anti-angiogenic factors, including angiopoietin-1 (ANGPT1), sphingosine 1-phosphate (S1P), thrombospondin-1 (TSP1), and endostatin [6]. The gene discussed is THBS1; the disease is neoplasm.