The various signalling pathways that were identified include: PI3K-Akt, Prostate cancer, Ras, Chemokine, HIF-1, FoxO, sphingolipid, AMPK, VEFG, JAK-STAT, insulin, GnRH, oestrogen, prolactin, thyroid hormone, relaxin, progesterone-mediated oocyte maturation, and progesterone. This evidence concerns the gene AKT1 and prostate cancer.