Notably, our findings indicated a significant downregulation of ANO7 and SLC38A4 expression in cancer tissues compared to normal tissues across various cancer types, including, but not limited to, Rectum adenocarcinoma (READ), Stomach Adenocarcinoma (STAD), Head and neck squamous cell carcinomas (HNSC), and colorectal cancer (COAD), as depicted in Fig. 5. This evidence concerns the gene SLC38A4 and rectum adenocarcinoma.