ANO7 and rectum adenocarcinoma: Notably, our findings indicated a significant downregulation of ANO7 and SLC38A4 expression in cancer tissues compared to normal tissues across various cancer types, including, but not limited to, Rectum adenocarcinoma (READ), Stomach Adenocarcinoma (STAD), Head and neck squamous cell carcinomas (HNSC), and colorectal cancer (COAD), as depicted in Fig. 5.