Montiel et al observed elevated NO levels in a pre-COVID-19 septic shock cohort compared to those with COVID-19, possibly due to neutrophil activation and cytokine-dependent inducible NO synthase68 induction in sepsis, while suggesting unique oxidative stress mechanisms unrelated to renin-Ang system hyperactivity or neutrophil activation in COVID-19.68 This evidence concerns the gene REN and COVID-19.