Firstly, we collected the arteries from the AD model rats for HE staining and then evaluated the severity of aortic aneurysm by elastin degradation score, the results showed that the aortic aneurysm in the AD+vector group was more severe than that in the Ctrl+vector group, indicating that the modelling was successful, and that the AD+sh-RBM15 group had a significant reduction in aortic aneurysm generation compared with the AD+vector group. Here, ELN is linked to Alzheimer disease.