CD4 and Alzheimer disease: The results of flow cytometry analysis of TIGIT expression in gated CD4+ T cells and Treg cells from peripheral total blood mononuclear cells derived from CRC mice are shown in Figure 3A-3C. Levels of CD4+TIGIT+ T cells were 13.42% ± 6.96 in controls, 12.19% ± 3.90 in AD mice, 10.20% ± 4.47 in SA mice, and 8.58% ± 3.53 in HA mice (Figure 3C).