A similar study including 757 CRC patients reached the same conclusion and also found that CRC with PIK3CA mutations were more likely to be associated with deficient expression of O-6-methylguanine-DNA methyltransferase (MGMT), which also leads to a significant decrease in the survival rate of patients with BRAF wild-type tumors44. The gene discussed is MGMT; the disease is colorectal carcinoma.