SMAD4 and colorectal adenocarcinoma: Interestingly, in another study64 involving 108 patients comparing colorectal adenocarcinoma with mucinous component (AWMC) and classic colorectal adenocarcinoma (AC), the most frequently mutated genes identified in AWMC were KRAS (45.4%), TP53 (39.8%), APC (22.2%), PIK3CA (22.2%) and SMAD4 (10.2%).