For instance, one study139 utilized phosphoproteomic data analysis to propose a theoretical foundation for targeting retinoblastoma protein (Rb) phosphorylation in colon cancer; this study also observed reduced CD8 T cell infiltration in MSI-H tumors along with increased glycolysis, suggesting that glycolysis could be a potential target to overcome immune checkpoint blockade resistance in MSI-H tumors. This evidence concerns the gene CD8A and malignant colon neoplasm.